Discovering small molecule therapeutics for Alzheimer's and other neurodegenerative diseases

Cognition Therapeutics Inc.

Mission

Cognition Therapeutics, Inc. is focused on the discovery and development of small molecule therapeutics targeting the toxic proteins that cause the cognitive decline associated with Alzheimer's disease and other degenerative diseases of the human brain. Toxic proteins play a crucial role in a large class of disease targets, and there are currently no therapeutics available to prevent toxic protein accumulation or block their destructive effects. Cognition is founded on the unique combination of biological expertise around these targets, including proprietary assays that emphasize functional responses and proprietary medicinal chemistry that insures novel, high quality small-molecule drug candidates.

 

The societal costs of neurodegenerative diseases are enormous; Alzheimer’s disease (AD) is the most common cognitive dementia, affecting one of every ten people over age 65 and nearly 35% over age 85. This translates into more than 4.5 million AD patients in the US alone, a number expected to reach 9 million by 2030 and 16 million by 2050 as the US population ages. As many as 25 million people worldwide are afflicted with less severe memory impairment known as mild cognitive impairment (MCI), which manifests several years before an actual clinical diagnosis of AD can be made. Patients suffering in the later stages of AD require nearly full-time care; in the US alone, the economic burden of AD is estimated to be in excess of $110B annually.

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